Description

1-(3-Chloro-2-Fluorophenyl)Ethan-1-Ol is a chiral fluorinated aromatic alcohol building block of significant synthetic utility. This compound matters as a versatile intermediate for constructing more complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and pesticides, where the fluorine and chlorine substituents can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, such as phosphines and oxazolines, to control stereochemistry in critical bond-forming reactions.
• Material Science Research: Employed in the synthesis of specialty monomers for advanced polymers with specific optical or electronic properties.
• Chemical Biology Probes: Useful for creating tagged molecules to study biological pathways and protein interactions in research settings.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-(3-Chloro-2-Fluorophenyl)Ethan-1-Ol
CAS No.	1339261-30-1
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	1-(3-Chloro-2-fluorophenyl)ethanol; (1R)-1-(3-Chloro-2-fluorophenyl)ethanol (enantiomer); (1S)-1-(3-Chloro-2-fluorophenyl)ethanol (enantiomer); α-Methyl-3-chloro-2-fluorobenzyl alcohol; 3-Chloro-2-fluoro-α-methylbenzyl alcohol; 2-Fluoro-3-chloro-α-methylbenzyl alcohol; (3-Chloro-2-fluorophenyl)methylcarbinol
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. For 1-(3-Chloro-2-Fluorophenyl)Ethan-1-Ol, this includes identity confirmation, chiral purity assessment, and quantification of organic impurities to meet the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are available upon request for every batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grades)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.