Description

tert-Butyl (3,3-Difluoropiperidin-4-Yl)(Methyl)Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a difluorinated piperidine scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of small molecule drugs, where its unique structure enables the exploration of new chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) for drug discovery and development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization, particularly for targets where fluorination enhances metabolic stability or binding affinity.
• Protease Inhibitor Development: Serves as a precursor in the synthesis of potential inhibitors for various enzymatic targets.
• Kinase Inhibitor Synthesis: Employed in the construction of complex molecules targeting kinase pathways in oncology and other disease areas.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Process Chemistry & Scale-up: Supplied for route scouting and optimization during the transition from laboratory to pilot and commercial-scale manufacturing.

Basic Information

Product Name	tert-Butyl (3,3-Difluoropiperidin-4-Yl)(Methyl)Carbamate
CAS No.	1334416-91-9
Molecular Formula	C11H20F2N2O2
Molecular Weight	262.29 g/mol
Synonyms	tert-Butyl N-methyl-N-(3,3-difluoropiperidin-4-yl)carbamate; 4-[[(1,1-Dimethylethoxy)carbonyl]methylamino]-3,3-difluoropiperidine; 3,3-Difluoro-4-[(methylcarbamoyl)oxy]piperidine tert-butyl ester; BOC-Protected 3,3-Difluoro-4-(methylamino)piperidine; tert-Butyl methyl(3,3-difluoropiperidin-4-yl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl (3,3-Difluoropiperidin-4-Yl)(Methyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.