Description

(S)-1-(tert-Butoxycarbonyl)-3,3-Dimethyl-1,3-Azasilolidine-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique azasilolidine scaffold. This compound is of significant value for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic disorders. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in process development and the production of novel therapeutic agents. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency for critical applications.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of proprietary drug candidates.
• Protease Inhibitor Development: Used in research and production of inhibitors targeting specific enzymatic pathways.
• Peptidomimetic Chemistry: The azasilolidine core is valuable for constructing conformationally constrained peptide analogs.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce stereochemical complexity.
• Medicinal Chemistry Research: Provides a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP-scale API production.

Basic Information

Product Name	(S)-1-(tert-Butoxycarbonyl)-3,3-Dimethyl-1,3-Azasilolidine-5-Carboxylic Acid
CAS No.	1334313-67-5
Molecular Formula	C13H25NO4Si
Molecular Weight	287.43 g/mol
Synonyms	(S)-1-Boc-3,3-dimethyl-1,3-azasilolidine-5-carboxylic acid; (S)-5-Carboxy-1-Boc-3,3-dimethyl-1,3-azasilolidine; (S)-1-(tert-Butoxycarbonyl)-3,3-dimethylazasilolidine-5-carboxylic acid; (S)-1-N-Boc-3,3-dimethyl-1,3-azasilolidine-5-carboxylic acid; Boc-Azasilolidine-5-COOH (S-isomer); (S)-3,3-Dimethyl-1-(tert-butoxycarbonyl)-1,3-azasilolidine-5-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of (S)-1-(tert-Butoxycarbonyl)-3,3-Dimethyl-1,3-Azasilolidine-5-Carboxylic Acid is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets the highest standards of purity and identity. Our quality system is designed to support cGMP-compliant applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as chiral purity, chemical purity (HPLC), and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.