Description

2-Chloro-4-(4-Fluoro-2-Methoxyphenyl)Pyridine is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring halogen and methoxy substituents, makes it a critical intermediate for constructing complex pharmacologically active molecules. This compound is primarily sought after by pharmaceutical R&D and fine chemical sectors for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used as a building block for creating advanced herbicides and fungicides, leveraging its halogenated pyridine core.
• Material Science Research: Serves as a precursor for the synthesis of functionalized ligands and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions for clinical trial materials.

Basic Information

Product Name	2-Chloro-4-(4-Fluoro-2-Methoxyphenyl)Pyridine
CAS No.	1333468-54-4
Molecular Formula	C₁₂H₉ClFNO
Molecular Weight	237.66 g/mol
Synonyms	2-Chloro-4-(4-fluoro-2-methoxyphenyl)pyridine; 4-(4-Fluoro-2-methoxyphenyl)-2-chloropyridine; 2-Chloro-4-(4-fluoro-2-methoxyphenyl)pyridine; Pyridine, 2-chloro-4-(4-fluoro-2-methoxyphenyl)-; 1333468-54-4
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity. Our products undergo comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with cGMP standards for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.