Description

(9R)-9-Isothiocyanato-Cinchonan CAS NO 1333118-34-5 is a high-purity, chiral alkaloid derivative of cinchona, specifically functionalized with an isothiocyanate group at the 9-position. This compound is a critical chiral building block and ligand for asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require advanced intermediates for catalysis and molecular recognition.

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand or organocatalyst for enantioselective transformations, such as Michael additions and aldol reactions.
• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Chiral Stationary Phase (CSP) Development: Used in the preparation of advanced materials for high-performance liquid chromatography (HPLC) to separate enantiomers.
• Chemical Biology & Medicinal Chemistry: Acts as a versatile scaffold for developing enzyme inhibitors and molecular probes due to its reactive isothiocyanate group.
• Agrochemical Synthesis: Employed in the research and development of chiral pesticides and herbicides.
• Academic & Industrial R&D: A valuable reference standard and starting material for novel methodological development in organic synthesis.

Basic Information

Product Name	(9R)-9-Isothiocyanato-Cinchonan
CAS No.	1333118-34-5
Molecular Formula	C20H23N3OS
Molecular Weight	353.48 g/mol
Synonyms	(9R)-9-Isothiocyanatocinchonan; (R)-9-Isothiocyanato-Cinchonan; 9-Isothiocyanatoquinidine; Cinchonan-9-yl isothiocyanate, (9R)-; (9R)-Cinchonan-9-yl isothiocyanate; (R)-Cinchonan-9-yl isothiocyanate; Quinidine-9-isothiocyanate; (9R)-9-Isothiocyanato-cinchonan alkaloid
EINECS	Contact for details

Quality Control

Our (9R)-9-Isothiocyanato-Cinchonan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.