Description

Foretinib H2O is a potent and selective small-molecule inhibitor of the c-Met (mesenchymal-epithelial transition factor) and VEGFR-2 (vascular endothelial growth factor receptor 2) tyrosine kinases. This dual-targeting mechanism makes it a critical research tool and a compound of significant interest in the development of novel cancer therapeutics. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on oncology. The compound is supplied as a high-purity, water-soluble form to facilitate in vitro and in vivo studies.

Application

• Oncology Research: Investigation of signaling pathways involving c-Met and VEGFR-2 in various cancer models, including lung, breast, and gastric cancers.
• Drug Discovery & Development: Used as a reference standard or active pharmaceutical ingredient (API) in preclinical studies for anti-angiogenic and anti-tumor agents.
• Biochemical Assays: Serves as a key inhibitor in enzymatic and cellular assays to study kinase function and validate drug targets.
• Mechanism of Action Studies: Elucidation of the role of c-Met and VEGFR-2 in tumor growth, metastasis, and resistance to other therapies.
• Academic Research: Fundamental research in molecular biology and pharmacology related to receptor tyrosine kinases and cancer biology.

Basic Information

Product Name	Foretinib H2O
CAS No.	1332889-22-1
Molecular Formula	C34H34F2N4O6
Molecular Weight	632.65 g/mol
Synonyms	Foretinib hydrate; GSK1363089; XL880 hydrate; N1-[3-Fluoro-4-[[6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinolin-4-yl]oxy]phenyl]-N3-(4-fluorophenyl)urea hydrate; EXEL-2880 hydrate; GSK089 hydrate
EINECS	Contact for details

Quality Control

Our Foretinib H2O is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.