Description

4-Hydroxy Guanabenz Hydrochloride is a high-purity chemical intermediate and reference standard of significant interest in pharmaceutical research and development. This compound matters as a key derivative of Guanabenz, enabling advanced studies into its pharmacological profile and potential therapeutic applications. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for investigating central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and process development of Guanabenz analogs and related pharmaceutical compounds.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control (QC) testing.
• Biochemical Research: Employed in preclinical studies to investigate the mechanism of action, metabolism, and structure-activity relationships (SAR) of α2-adrenergic receptor agonists.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the R&D of new drug candidates targeting hypertension and neurological conditions.
• Metabolite Studies: Utilized as an analytical standard for the identification and quantification of Guanabenz metabolites in pharmacokinetic and bioanalytical research.

Basic Information

Product Name	4-Hydroxy Guanabenz Hydrochloride
CAS No.	1331636-59-9
Molecular Formula	C8H8Cl2N4O • HCl
Molecular Weight	279.54 g/mol (Free base: 243.08 g/mol)
Synonyms	4-Hydroxyguanabenz HCl; Guanabenz Hydroxy Derivative Hydrochloride; (2,6-Dichlorobenzylidene)amino-4-hydroxyguanidine Hydrochloride; 1-[(2,6-Dichlorobenzylidene)amino]-3-hydroxyguanidine Hydrochloride; 4-OH-Guanabenz HCl; 4-Hydroxy Guanabenz HCl Salt; Guanabenz Impurity/Intermediate; 4-Hydroxy Derivative of Guanabenz Acetate Hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Guanabenz Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and is supplied with a detailed Certificate of Analysis (COA) that includes results for identity, purity, and related substances. We support development and regulatory needs with materials suitable for use as pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.