Description

(R)-Simurosertib is a high-purity, enantiomerically pure small molecule compound designed for advanced pharmaceutical research and development. This compound serves as a critical intermediate or active pharmaceutical ingredient (API) in the development of targeted cancer therapies, specifically functioning as a potent and selective inhibitor. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on oncology drug discovery, preclinical studies, and process development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel oncology drug candidates.
• Active Pharmaceutical Ingredient (API): For use in the formulation of investigational new drugs targeting specific kinase pathways.
• Biochemical Research: A vital tool compound for in vitro and in vivo studies to investigate cancer cell signaling and mechanism of action.
• Preclinical Development: Used in pharmacokinetic, pharmacodynamic, and toxicology studies to support IND (Investigational New Drug) applications.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in API manufacturing.
• Process Chemistry: Employed in route scouting and optimization for scalable GMP (Good Manufacturing Practice) production.

Basic Information

Product Name	(R)-Simurosertib
CAS No.	1330782-69-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-TAK-931; (R)-Simurosertib; (R)-3-(2,3-Difluorophenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide; TAK-931 (R-enantiomer); Simurosertib R-isomer; (R)-CDC7 Inhibitor; (R)-Cell division cycle 7 kinase inhibitor
EINECS	Contact for details

Quality Control

Our (R)-Simurosertib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification, potency assay, and impurity profiling. A Certificate of Analysis (COA) detailing identity, purity (by HPLC), and related substances is provided with every shipment to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.