Description

5-Bromo-4-Methyl-3-((Trimethylsilyl)Ethynyl)Pyridin-2-Amine is a high-value, multi-functional pyridine derivative featuring a bromo substituent and a protected ethynyl group. This compound matters as a critical advanced pharmaceutical intermediate and versatile organic building block for complex synthesis. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of kinase inhibitors, targeted cancer therapies, and other small molecule active pharmaceutical ingredients (APIs).
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and plant growth regulators with enhanced activity.
• Material Science: Used in the development of organic semiconductors, liquid crystals, and advanced polymers due to its conjugated system and functional handles.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Click Chemistry: The protected alkyne group can be deprotected for use in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
• Chemical Biology: Serves as a probe or linker in bioconjugation strategies and the development of chemical tools for biological study.

Basic Information

Item	Details
Product Name	5-Bromo-4-Methyl-3-((Trimethylsilyl)Ethynyl)Pyridin-2-Amine
CAS No.	1326216-30-1
Molecular Formula	C11H15BrN2Si
Molecular Weight	283.24 g/mol
Synonyms	2-Amino-5-bromo-4-methyl-3-[(trimethylsilyl)ethynyl]pyridine; 5-Bromo-4-methyl-3-(2-trimethylsilylethynyl)pyridin-2-amine; 3-((Trimethylsilyl)ethynyl)-5-bromo-4-methylpyridin-2-amine; 5-Bromo-4-methyl-3-((trimethylsilyl)ethynyl)-2-pyridinamine; 2-Pyridinamine, 5-bromo-4-methyl-3-[(trimethylsilyl)ethynyl]-; TMS-protected ethynyl pyridine intermediate
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Methyl-3-((Trimethylsilyl)Ethynyl)Pyridin-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.