Description

4-Fluoro-2-(Trifluoromethoxy)Benzoyl Chloride, 97% is a high-purity, reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to efficiently introduce the 4-fluoro-2-(trifluoromethoxy)benzoyl moiety, a key structural motif that can impart desirable properties like metabolic stability and lipophilicity to target molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Production: Serves as a building block for advanced electronic materials, contributing to the molecular framework of compounds used in displays and organic light-emitting diodes.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and polyamides, where it can modify polymer backbones to achieve specific thermal or chemical resistance properties.
• Peptide & Protein Modification: Acts as an acylating agent for modifying amino acids, peptides, or other biomolecules in biochemical research and drug conjugate development.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Fluoro-2-(Trifluoromethoxy)Benzoyl Chloride, 97%
CAS No.	1323966-38-6
Molecular Formula	C8H3ClF4O2
Molecular Weight	242.56 g/mol
Synonyms	4-Fluoro-2-(trifluoromethoxy)benzoyl chloride; 2-(Trifluoromethoxy)-4-fluorobenzoyl chloride; 4-Fluoro-α,α,α-trifluoro-o-anisoyl chloride; 4-Fluoro-2-trifluoromethoxybenzoic acid chloride; Benzoyl chloride, 4-fluoro-2-(trifluoromethoxy)-; 1323966-38-6
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-(Trifluoromethoxy)Benzoyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment. Our quality system is designed to support cGMP (current Good Manufacturing Practice) requirements for use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.