Description

5-Iodo-4-(Trifluoromethyl)Pyridin-2-Amine is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both iodine and trifluoromethyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine core and halogen substituents.
• Material Science: Building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-deficient aromatic system.
• Chemical Synthesis: Versatile reagent for cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitutions, facilitated by the reactive iodine atom.
• Life Science Research: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a molecular probe.
• Fluorine Chemistry: Serves as a valuable scaffold for introducing the metabolically stable trifluoromethyl group into more complex molecules.

Basic Information

Product Name	5-Iodo-4-(Trifluoromethyl)Pyridin-2-Amine
CAS No.	1321530-57-7
Molecular Formula	C6H4F3IN2
Molecular Weight	288.01 g/mol
Synonyms	2-Amino-5-iodo-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-5-iodopyridin-2-amine; 5-Iodo-4-trifluoromethylpyridin-2-amine; 2-Pyridinamine, 5-iodo-4-(trifluoromethyl)-; 1321530-57-7
EINECS	Contact for details

Quality Control

Our 5-Iodo-4-(Trifluoromethyl)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.