Description

Citarinostat CAS NO 1316215-12-9 is a potent and selective small molecule inhibitor of histone deacetylase 6 (HDAC6). This compound matters as a key research tool for investigating epigenetic regulation, protein degradation pathways, and their roles in oncology and neurodegenerative diseases. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and preclinical studies for cancer and other therapeutic areas.

Application

• Biomedical Research: Used as a selective HDAC6 inhibitor to study acetylation dynamics, aggresome formation, and chaperone function in cellular models.
• Oncology Research: Investigated for its potential anti-tumor effects, particularly in hematological malignancies and solid tumors, often in combination with other therapeutic agents.
• Neurodegenerative Disease Research: Employed in studies targeting tauopathy, protein misfolding, and neuroinflammation associated with conditions like Alzheimer's disease.
• Immunology Research: Applied to modulate immune cell function and cytokine production in various inflammatory and autoimmune disease models.
• Chemical Biology: Serves as a critical probe compound for validating HDAC6-specific phenotypes and for target engagement studies in complex biological systems.
• Preclinical Development: Utilized in pharmacokinetic, pharmacodynamic, and toxicology studies to support the development of novel HDAC6-targeted therapeutics.

Basic Information

Product Name	Citarinostat
CAS No.	1316215-12-9
Molecular Formula	C₂₁H₂₀N₄O₃S
Molecular Weight	408.47 g/mol
Synonyms	ACY-241; Citarinostat (ACY-241); N-(4-((2-(2-Aminopyrimidin-5-yl)-4-(morpholin-4-yl)phenyl)amino)quinazolin-6-yl)acrylamide; Acrylamide, N-[4-[[2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)phenyl]amino]-6-quinazolinyl]-; ACY 241; ACY241
EINECS	Contact for details

Quality Control

Our Citarinostat is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep container dry and in a well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	<20 ppm
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.