Description

n-[(Dimethylamino)Methylene]-2',3'-o-(Methoxymethylene)Guanosine is a chemically modified nucleoside derivative, serving as a crucial protected intermediate in oligonucleotide synthesis. Its primary value lies in enabling the precise and efficient construction of RNA and DNA sequences for research and therapeutic development. This high-purity building block is essential for pharmaceutical R&D, biotechnology companies, and academic laboratories focused on antisense technology, siRNA, and other nucleic acid-based applications.

Application

• Oligonucleotide Synthesis: A key protected monomer for the solid-phase synthesis of RNA and DNA strands.
• Antisense Oligonucleotide (ASO) Development: Used in the research and production of therapeutic ASOs targeting genetic diseases.
• Small Interfering RNA (siRNA) Manufacturing: A critical intermediate for constructing siRNA duplexes used in gene silencing applications.
• Pharmaceutical Research: Serves as a building block for novel nucleoside analogs and prodrugs in drug discovery programs.
• Diagnostic Probe Development: Utilized in the creation of labeled probes for genetic testing and molecular diagnostics.
• Academic & Contract Research: Supports fundamental research in biochemistry, molecular biology, and medicinal chemistry.

Basic Information

Item	Details
Product Name	n-[(Dimethylamino)Methylene]-2',3'-o-(Methoxymethylene)Guanosine
CAS No.	1315092-28-4
Molecular Formula	C15H22N6O6
Molecular Weight	382.37 g/mol
Synonyms	2',3'-O-(Methoxymethylene)guanosine N-[(dimethylamino)methylene] derivative; DMTr-G(MOM) Phosphoramidite precursor; N-[(Dimethylamino)methylene]-2',3'-O-(methoxymethylene)guanosine; Protected Guanosine Derivative; Guanosine, N-[(dimethylamino)methylene]-2',3'-O-(methoxymethylene)-; RNA Synthesis Building Block
EINECS	Contact for details

Quality Control

Our n-[(Dimethylamino)Methylene]-2',3'-o-(Methoxymethylene)Guanosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.