Description

2-Amino-5-(4-Cbz-Aminophenyl)Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a pyridine core with protected amine functionalities. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of targeted therapeutics, including kinase inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, particularly in oncology and CNS research.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis.
• Kinase Inhibitor Development: The structural motif is valuable for creating potential inhibitors targeting specific protein kinases.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and drug discovery programs.

Basic Information

Product Name	2-Amino-5-(4-Cbz-Aminophenyl)Pyridine
CAS No.	1314987-26-2
Molecular Formula	C19H17N3O2
Molecular Weight	319.36 g/mol
Synonyms	5-(4-((Benzyloxy)carbonylamino)phenyl)pyridin-2-amine; N-Cbz-4-(6-Aminopyridin-3-yl)aniline; 2-Amino-5-[4-[(phenylmethoxy)carbonylamino]phenyl]pyridine; 4-(6-Aminopyridin-3-yl)phenyl (benzyloxy)carbamate; 2-Amino-5-(4-carbobenzyloxyaminophenyl)pyridine; CBZ-Protected Aminophenylpyridine Derivative
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-5-(4-Cbz-Aminophenyl)Pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request, supporting compliance with cGMP and other relevant quality guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if necessary after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.