Description

5-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazolo[3,4-B]Pyridine-3-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its brominated pyrazolopyridine core protected by a tetrahydropyranyl (THP) group. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of novel, complex heterocyclic molecules with potential biological activity. It is primarily needed by R&D organizations and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule drugs, particularly kinase inhibitors and other therapeutic agents.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Agrochemical Development: Serves as a building block for creating novel crop protection agents and pesticides.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific compounds under cGMP conditions.
• Academic Research: Employed in university and institutional labs for fundamental research in organic and heterocyclic chemistry.

Basic Information

Product Name	5-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazolo[3,4-B]Pyridine-3-Carbaldehyde
CAS No.	1314734-59-2
Molecular Formula	C12H12BrN3O2
Molecular Weight	310.15 g/mol
Synonyms	5-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-3-carboxaldehyde; 5-Bromo-1-(THP)-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde; 1-(Tetrahydro-2H-pyran-2-yl)-5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde; 5-Bromo-1-(2-tetrahydropyranyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxaldehyde; 1314734-59-2; 5-Bromo-1-THP-pyrazolo[3,4-b]pyridine-3-carbaldehyde
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazolo[3,4-B]Pyridine-3-Carbaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for each shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the primary container to minimize degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.