Description

[1-(Difluoromethyl)Cyclopropyl]Methanol is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its unique structure, featuring a cyclopropane ring and a difluoromethylated alcohol moiety, makes it a critical intermediate for introducing conformational rigidity and fluorine atoms into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to optimize the potency, metabolic stability, and bioavailability of new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoromethyl group can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and fluorinated materials with unique surface properties.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Fluorine Chemistry Research: A valuable substrate for studying new fluorination methodologies and the physicochemical effects of fluorine substitution in organic compounds.

Basic Information

Product Name	[1-(Difluoromethyl)Cyclopropyl]Methanol
CAS No.	1314402-08-8
Molecular Formula	C5H8F2O
Molecular Weight	122.11 g/mol
Synonyms	(1-(Difluoromethyl)cyclopropyl)methanol; 1-(Difluoromethyl)cyclopropanemethanol; Cyclopropanemethanol, 1-(difluoromethyl)-; (1-(Difluoromethyl)cyclopropyl)carbinol
EINECS	Contact for details

Quality Control

Our [1-(Difluoromethyl)Cyclopropyl]Methanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.