Description

1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 5-Chloro-2-Methyl-, Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers targeting innovative therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacophores.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold in the multi-step synthesis of potential APIs for oncology and central nervous system (CNS) disorders.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard for analytical method development and validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 5-Chloro-2-Methyl-, Methyl Ester
CAS No.	1312755-54-6
Molecular Formula	C10H9ClN2O2
Molecular Weight	224.64 g/mol
Synonyms	5-Chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; Methyl 5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate; 5-Chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-chloro-2-methyl-, methyl ester; CAS 1312755-54-6
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 5-Chloro-2-Methyl-, Methyl Ester adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.