Description

tert-Butyl4,6-Dichloro-7-Fluoro-3-Oxo-1,3-Dihydro-2H-Pyrrolo[3,4-C]Pyridine-2-Carboxylate CAS NO 1312693-67-6 is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused pyrrolopyridine structure. This compound is of critical importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and other therapeutic areas. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of next-generation small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug candidates, especially kinase inhibitors.
• Oncology Drug Development: Used in research and production of targeted cancer therapies due to its specific heterocyclic scaffold.
• Medicinal Chemistry Research: Employed as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• API Synthesis: Integral in the final stages of synthesizing active pharmaceutical ingredients requiring this specific chlorinated and fluorinated pyrrolopyridine core.
• Contract Manufacturing: Supplied to CDMOs for cGMP production of clinical trial materials and commercial drug substances.
• Process Chemistry Optimization: Used in scaling up and optimizing synthetic routes from laboratory to pilot plant and commercial production.

Basic Information

Product Name	tert-Butyl4,6-Dichloro-7-Fluoro-3-Oxo-1,3-Dihydro-2H-Pyrrolo[3,4-C]Pyridine-2-Carboxylate
CAS No.	1312693-67-6
Molecular Formula	C₁₂H₁₀Cl₂FNO₃
Molecular Weight	306.12 g/mol
Synonyms	tert-Butyl 4,6-dichloro-7-fluoro-3-oxo-1,3-dihydro-2H-pyrrolo[3,4-c]pyridine-2-carboxylate; 2H-Pyrrolo[3,4-c]pyridine-2-carboxylic acid, 4,6-dichloro-1,3-dihydro-7-fluoro-3-oxo-, 1,1-dimethylethyl ester; 4,6-Dichloro-7-fluoro-3-oxo-1,3-dihydro-2H-pyrrolo[3,4-c]pyridine-2-carboxylic acid tert-butyl ester; BOC-protected 4,6-dichloro-7-fluoro-3-oxo-pyrrolopyridine; 1312693-67-6
EINECS	Contact for details

Quality Control

Our tert-Butyl4,6-Dichloro-7-Fluoro-3-Oxo-1,3-Dihydro-2H-Pyrrolo[3,4-C]Pyridine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.