Description

Buparlisib Hydrochloride is a potent and selective oral pan-class I phosphatidylinositol 3-kinase (PI3K) inhibitor. This compound matters significantly as a key research tool and pharmaceutical intermediate for developing targeted cancer therapies, particularly in oncology research. It is primarily needed by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on investigating PI3K pathway dysregulation in various cancers.

Application

• Pharmaceutical Intermediate: Critical raw material in the synthesis of final drug formulations for clinical development.
• Oncology Research: Used as a reference standard and active compound in preclinical studies targeting PI3K/AKT/mTOR signaling pathways.
• Biochemical Assay Development: Serves as a potent inhibitor in cell-based and enzymatic assays to study PI3K biology and inhibitor selectivity.
• Drug Discovery & Development: Employed in hit-to-lead optimization and pharmacokinetic/pharmacodynamic (PK/PD) modeling studies.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of drug substances and products.
• Mechanistic Studies: Facilitates research into resistance mechanisms and combination therapy strategies for solid tumors and hematologic malignancies.

Basic Information

Product Name	Buparlisib Hydrochloride
CAS No.	1312445-63-8
Molecular Formula	C22H23ClN6O2
Molecular Weight	438.91 g/mol
Synonyms	BKM120 Hydrochloride; NVP-BKM120 Hydrochloride; Buparlisib HCl; 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine Hydrochloride; BKM 120 HCl; NVP-BKM 120 HCl; AN-2025 Hydrochloride
EINECS	Contact for details

Quality Control

Our Buparlisib Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high-grade standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.