Description

5-Chloro-2-Fluoropyridine-4-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, such as Suzuki-Miyaura couplings, to construct complex heterocyclic scaffolds. This compound is critically needed by pharmaceutical, agrochemical, and advanced materials researchers for the development of new active ingredients and functional molecules. Its specific substitution pattern offers precise control over molecular architecture in drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, infections, and oncology.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a versatile coupling partner to introduce the 5-chloro-2-fluoropyridine moiety into more complex molecular systems.
• Ligand and Catalyst Development: Employed in the research and synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	5-Chloro-2-Fluoropyridine-4-Boronic Acid Pinacol Ester
CAS No.	1310383-58-4
Molecular Formula	C11H14BClFNO2
Molecular Weight	255.50 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(5-chloro-2-fluoropyridin-4-yl)-1,3,2-dioxaborolane; (5-Chloro-2-fluoropyridin-4-yl)boronic acid pinacol ester; 5-Chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-(5-Chloro-2-fluoro-4-pyridinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Chloro-2-fluoro-4-pyridineboronic acid pinacol ester; Boronic acid, B-(5-chloro-2-fluoro-4-pyridinyl)-, 1,1-dimethylethyl ester; CAS 1310383-58-4
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoropyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance in cross-coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports applications in cGMP and ISO-compliant environments for pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.