Description

cis-6-Benzyl-4-Oxo-Octahydro-Pyrrolo[3,4-B]Pyridine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex fused pyrrolopyridine scaffold. This compound is critical for medicinal chemistry research and development, serving as a key building block for the synthesis of novel therapeutic agents. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for creating new drug candidates targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Protease Inhibitor Synthesis: The pyrrolopyridine core structure is valuable for constructing molecules that modulate protease enzyme activity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and reference standards.
• Academic Research: Employed in university and institutional labs for studying novel heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	cis-6-Benzyl-4-Oxo-Octahydro-Pyrrolo[3,4-B]Pyridine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1310381-21-5
Molecular Formula	C20H26N2O3
Molecular Weight	342.44 g/mol
Synonyms	tert-Butyl cis-6-benzyl-4-oxohexahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate; 1H-Pyrrolo[3,4-b]pyridine-1-carboxylic acid, 2,3,3a,4,5,6-hexahydro-6-benzyl-4-oxo-, 1,1-dimethylethyl ester, cis-; (3aR,6S)-6-Benzyl-4-oxo-2,3,3a,4,5,6-hexahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester; cis-6-Benzyl-4-oxo-octahydro-pyrrolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester; BOC-protected pyrrolopyridine intermediate.
EINECS	Contact for details

Quality Control

Every batch of cis-6-Benzyl-4-Oxo-Octahydro-Pyrrolo[3,4-B]Pyridine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.