Description

2-tert-Butyloxycarbonylamino-5-Fluoropyridine-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry and drug discovery. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel, complex molecules targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing fluorinated pyridine scaffolds.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester moiety enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, a cornerstone of modern heterocyclic chemistry.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and library synthesis to explore structure-activity relationships (SAR) for new drug candidates.
• Agrochemical Research: Serves as a precursor in the development of novel pesticides and herbicides that incorporate fluorinated heterocycles for enhanced activity.
• Chemical Biology Probes: Can be utilized to create tagged molecules for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: The Boc-protected amine offers stability during synthesis, making it suitable for developing robust and scalable manufacturing routes.

Basic Information

Product Name	2-tert-Butyloxycarbonylamino-5-Fluoropyridine-3-Boronic Acid Pinacol Ester
CAS No.	1309981-29-0
Molecular Formula	C16H24BFN2O4
Molecular Weight	338.19 g/mol
Synonyms	5-Fluoro-2-((tert-butoxycarbonyl)amino)pyridine-3-boronic acid pinacol ester; 2-(Boc-amino)-5-fluoropyridine-3-boronic acid pinacol ester; 2-((tert-Butoxycarbonyl)amino)-5-fluoropyridine-3-boronic acid pinacol ester; Boc-5-Fluoro-2-aminopyridine-3-Boronic Acid Pinacol Ester; 3-Borono-5-fluoro-2-((tert-butoxycarbonyl)amino)pyridine pinacol ester; N-Boc-2-Amino-5-fluoro-3-pyridineboronic acid pinacol ester; 1309981-29-0
EINECS	Contact for details

Quality Control

Our 2-tert-Butyloxycarbonylamino-5-Fluoropyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.