Description

2-Fluoro-6-(Pyrrolidin-1-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in kinase inhibitor and CNS-targeted therapeutic research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides requiring specific fluorinated pyridine scaffolds.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for OLEDs and charge-transport molecules.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the synthesis of activity-based probes for target identification and validation.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening (HTS) campaigns.
• Catalyst and Ligand Development: Serves as a precursor for novel organoboron catalysts and chiral ligands used in asymmetric synthesis.

Basic Information

Product Name	2-Fluoro-6-(Pyrrolidin-1-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1309980-28-6
Molecular Formula	C15H22BFN2O2
Molecular Weight	292.16 g/mol
Synonyms	2-Fluoro-6-(pyrrolidin-1-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-6-(1-pyrrolidinyl)pyridine; 2-Fluoro-6-pyrrolidin-1-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol 2-Fluoro-6-(pyrrolidin-1-yl)pyridine-4-boronate; 1309980-28-6; 2-Fluoro-6-(1-pyrrolidinyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and LC-MS to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic data are available upon request, providing full traceability and supporting regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Optimal storage temperature is between 2°C and 8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.