Description

[3-(Difluoromethyl)Phenyl]Methanol, also known as 3-(Hydroxymethyl)Benzal Fluoride, is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic incorporation of both a reactive benzylic alcohol and a difluoromethyl group onto a benzene ring, enabling precise molecular modifications. This compound is primarily sought after by R&D chemists and process developers in the pharmaceutical and agrochemical industries for constructing complex molecules, where the difluoromethyl moiety can enhance metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoromethyl group can improve pesticidal activity and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for advanced display technologies (LCDs).
• Organic Electronics: Employed in the development of novel organic semiconductors and charge-transport materials for OLEDs and photovoltaic cells.
• Fluorinated Polymer Modifiers: Acts as a monomer or cross-linking agent to introduce fluorine into polymer backbones, enhancing chemical resistance and thermal stability.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and constructing diverse compound libraries for high-throughput screening.

Basic Information

Product Name	[3-(Difluoromethyl)Phenyl]Methanol / 3-(Hydroxymethyl)Benzal Fluoride
CAS No.	1309875-03-3
Molecular Formula	C8H8F2O
Molecular Weight	158.15 g/mol
Synonyms	(3-(Difluoromethyl)phenyl)methanol; 3-(Difluoromethyl)benzyl alcohol; α,α-Difluoro-m-tolylmethanol; m-(Difluoromethyl)benzyl alcohol; 3-(Hydroxymethyl)benzal fluoride; 1-(Difluoromethyl)-3-(hydroxymethyl)benzene; 3-(Difluoromethyl)benzenemethanol
EINECS	Contact for details

Quality Control

Our [3-(Difluoromethyl)Phenyl]Methanol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.