Description

1-(5-Fluoropyridin-3-Ylsulfonyl)Piperidin-2-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique sulfonamide-linked piperidine-pyridine scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for constructing novel bioactive molecules. It is primarily sought by researchers and process chemists in the pharmaceutical and biotechnology industries for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, inflammation, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Protease Inhibitor Development: The sulfonamide and amine functionalities make it a candidate for designing inhibitors of various enzymes, including kinases and proteases.
• Ligand Synthesis for Receptor Targeting: Employed in the creation of novel ligands for G-protein-coupled receptors (GPCRs) and other biological targets.
• Chemical Biology Probes: Useful for developing tool compounds and probes to study biological pathways and disease mechanisms.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	1-(5-Fluoropyridin-3-Ylsulfonyl)Piperidin-2-Amine
CAS No.	1306432-47-2
Molecular Formula	C10H13FN4O2S
Molecular Weight	272.30 g/mol
Synonyms	1-[(5-Fluoropyridin-3-yl)sulfonyl]piperidin-2-amine; 2-Amino-1-(5-fluoropyridine-3-sulfonyl)piperidine; 1306432-47-2; 1-(5-Fluoro-3-pyridinylsulfonyl)-2-piperidinamine; Piperidin-2-amine, 1-[(5-fluoropyridin-3-yl)sulfonyl]-; 1-(5-Fluoropyridine-3-sulfonyl)piperidin-2-amine
EINECS	Contact for details

Quality Control

Our 1-(5-Fluoropyridin-3-Ylsulfonyl)Piperidin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with research-grade or cGMP standards based on customer project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.