Description

(E)-Methyl 3-(1H-Pyrazolo[3,4-B]Pyridin-5-Yl)Acrylate is a high-value pharmaceutical intermediate and versatile building block in organic synthesis. This compound is critical for the development of novel therapeutic agents, particularly in kinase inhibitor research and other targeted drug discovery programs. It is primarily sought after by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in producing active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Organic Synthesis Building Block: The acrylate moiety and heterocyclic core enable diverse chemical transformations, including cycloadditions and cross-coupling reactions.
• Agrochemical Development: Potential application in the synthesis of novel crop protection agents and herbicides.
• Material Science Research: Investigated as a monomer or precursor for functional polymers and advanced organic materials.

Basic Information

Product Name	(E)-Methyl 3-(1H-Pyrazolo[3,4-B]Pyridin-5-Yl)Acrylate
CAS No.	1305332-65-3
Molecular Formula	C10H9N3O2
Molecular Weight	203.20 g/mol
Synonyms	Methyl (E)-3-(1H-pyrazolo[3,4-b]pyridin-5-yl)acrylate; Methyl 3-(1H-Pyrazolo[3,4-b]pyridin-5-yl)-2-propenoate; 1H-Pyrazolo[3,4-b]pyridine-5-acrylic acid methyl ester; 5-(2-Methoxycarbonylvinyl)-1H-pyrazolo[3,4-b]pyridine; (E)-Methyl 3-(1H-pyrazolo[3,4-b]pyridin-5-yl)acrylate; 1305332-65-3; Methyl 3-(1H-pyrazolo[3,4-b]pyridin-5-yl)acrylate (E)-isomer
EINECS	Contact for details

Quality Control

Our (E)-Methyl 3-(1H-Pyrazolo[3,4-B]Pyridin-5-Yl)Acrylate is manufactured under strict quality management systems. We provide material with typical purity grades of 95% to 98%+ (HPLC), tailored to meet specific project requirements. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality commitment ensures material suitable for demanding applications in pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.