Description

tert-Butyl 5-(3-Hydroxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique pyrazolopyridine scaffold functionalized with a hydroxylated alkyne moiety. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small molecule therapeutics, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable functional groups.
• Bioconjugation & Probe Development: The alkyne handle allows for click chemistry applications, useful in creating chemical probes for biological target identification.
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the development and optimization of commercial-scale API (Active Pharmaceutical Ingredient) manufacturing routes.
• Academic Research: Employed in university and institutional labs for exploring new heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	tert-Butyl 5-(3-Hydroxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate
CAS No.	1305325-07-8
Molecular Formula	C15H17N3O3
Molecular Weight	287.32 g/mol
Synonyms	1-Boc-5-(3-hydroxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-b]pyridine; tert-Butyl 5-(3-hydroxy-1-propynyl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate; 5-(3-Hydroxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester; 1H-Pyrazolo[3,4-b]pyridine-1-carboxylic acid, 5-(3-hydroxy-1-propyn-1-yl)-, 1,1-dimethylethyl ester; 1305325-07-8; Boc-protected 5-ethynylpyrazolopyridine alcohol
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(3-Hydroxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete analytical data are provided for each lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.