Description

tert-Butyl 5-((Trimethylsilyl)ethynyl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrazolopyridine core with a versatile ethynyl handle. This compound is specifically engineered for use in modern drug discovery, particularly in the synthesis of targeted kinase inhibitors and other bioactive molecules. It is an essential building block for medicinal chemistry research and development teams in the pharmaceutical and biotechnology sectors seeking to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of kinase inhibitors and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its modifiable ethynyl group.
• Chemical Biology Probes: Serves as a scaffold for creating chemical probes to study biological pathways and protein functions.
• Cross-Coupling Reactions: The trimethylsilyl-protected alkyne moiety is a strategic functional group for Sonogashira and other palladium-catalyzed cross-coupling reactions.
• API Synthesis: Employed in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical development.

Basic Information

Product Name	tert-Butyl 5-((Trimethylsilyl)ethynyl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate
CAS No.	1305325-05-6
Molecular Formula	C18H25N3O2Si
Molecular Weight	343.50 g/mol
Synonyms	1-Boc-5-((trimethylsilyl)ethynyl)-1H-pyrazolo[3,4-b]pyridine; tert-Butyl 5-((trimethylsilyl)ethynyl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate; 1H-Pyrazolo[3,4-b]pyridine-1-carboxylic acid, 5-[(trimethylsilyl)ethynyl]-, 1,1-dimethylethyl ester; 5-((Trimethylsilyl)ethynyl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester; 1305325-05-6; TMS-ethynyl pyrazolopyridine Boc-protected
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-((Trimethylsilyl)ethynyl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.