Description

5-Chloro-7-Azaindole-6-Carboxylic Acid Methyl Ester is a high-value heterocyclic building block and advanced pharmaceutical intermediate. Its core value lies in its functionalized azaindole scaffold, which is a privileged structure in medicinal chemistry for designing novel bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of kinase inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel kinase inhibitors (e.g., JAK, ALK, EGFR inhibitors) and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its versatile azaindole core.
• Agrochemical Synthesis: Serves as a building block for creating new active ingredients with potential herbicidal or insecticidal properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring functionalized nitrogen-containing heterocycles.

Basic Information

Product Name	5-Chloro-7-Azaindole-6-Carboxylic Acid Methyl Ester
CAS No.	1305324-76-8
Molecular Formula	C9H7ClN2O2
Molecular Weight	210.62 g/mol
Synonyms	Methyl 5-chloro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate; 5-Chloro-1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid methyl ester; 5-Chloro-7-azaindole-6-methyl carboxylate; 6-(Methoxycarbonyl)-5-chloro-7-azaindole; 1305324-76-8; 5-Chloro-7-aza-indole-6-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 5-Chloro-7-Azaindole-6-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive and should be handled under inert atmosphere for long-term storage to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Related Substances (HPLC)	Individual impurity ≤1.0%
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.