Description

Sar405838 (Mi-773) is a potent and selective small molecule inhibitor of the p53-MDM2 protein-protein interaction. This compound is of significant value in oncology research for its ability to reactivate the p53 tumor suppressor pathway in cancer cells with wild-type p53. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel cancer therapeutics and studying p53 biology.

Application

• Oncology Drug Discovery: A key research tool for evaluating the therapeutic potential of MDM2 inhibition in various cancer models.
• Mechanistic Studies: Used to investigate the p53 signaling pathway, apoptosis induction, and cell cycle regulation in vitro and in vivo.
• Preclinical Development: Serves as a reference compound or lead molecule for developing next-generation MDM2-p53 interaction inhibitors.
• Combination Therapy Research: Explored in studies combining MDM2 inhibition with other anticancer agents (e.g., chemotherapy, targeted therapy) to enhance efficacy.
• Biochemical Assays: Employed in high-throughput screening (HTS) and binding assays to characterize MDM2-p53 interactions.
• SAR (Structure-Activity Relationship) Studies: Used as a core structure for medicinal chemistry optimization programs.

Basic Information

Product Name	Sar405838 (Mi-773)
CAS No.	1303607-60-4
Molecular Formula	C30H31ClF3N5O3S
Molecular Weight	634.11 g/mol
Synonyms	MI-773; MI 773; SAR405838; SAR 405838; 4-[[4-[(4S)-2-(4-Chlorophenyl)-4,5-bis(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-3-(trifluoromethyl)benzenesulfonamide; 1-(4-Chlorophenyl)-2,2-bis(4-methoxyphenyl)-N-[4-(4-[[3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl)phenyl]ethanimidamide
EINECS	Contact for details

Quality Control

Our Sar405838 (Mi-773) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. Keep the container sealed and dry.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.