Description

5-Bromo-2,3-diiodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine is a highly functionalized, multi-halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its complex molecular architecture, featuring bromine, iodine, and a phenylsulfonyl protecting group, makes it a critical intermediate for constructing sophisticated nitrogen-containing scaffolds. This compound is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, particularly in kinase inhibitor and other small-molecule drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used to develop novel active ingredients for crop protection with potential new modes of action.
• Chemical Biology Probe Synthesis: Serves as a building block for creating molecular probes to study biological pathways and protein functions.
• Material Science Research: Potential precursor for the development of organic electronic materials and ligands for catalysis.
• Cross-Coupling Reactions: The bromo and iodo substituents are excellent handles for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological screening.

Basic Information

Product Name	5-Bromo-2,3-diiodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.	1299607-59-2
Molecular Formula	C13H7BrI2N2O2S
Molecular Weight	604.98 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-bromo-2,3-diiodo-1-(phenylsulfonyl)-; 5-Bromo-2,3-diiodo-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Phenylsulfonyl)-5-bromo-2,3-diiodo-1H-pyrrolo[2,3-b]pyridine; 1299607-59-2; 5-Br-2,3-I2-1-PhSO2-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our high-purity research-grade 5-Bromo-2,3-diiodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.