Description

1-Boc-5-Bromo-1H-Pyrazolo[3,4-B]Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a brominated pyrazolopyridine core protected by a tert-butoxycarbonyl (Boc) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by researchers and process chemists in the pharmaceutical and biotechnology industries for creating targeted small-molecule therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns for constructing complex heterocyclic scaffolds with potential biological activity.
• Kinase Inhibitor Development: The pyrazolopyridine structure is a privileged scaffold in the design of protein kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study enzyme function and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.
• Agrochemical Research: Potential intermediate in the discovery of new agrochemicals, leveraging its heterocyclic structure.

Basic Information

Product Name	1-Boc-5-Bromo-1H-Pyrazolo[3,4-B]Pyridine
CAS No.	1299607-55-8
Molecular Formula	C11H12BrN3O2
Molecular Weight	298.14 g/mol
Synonyms	5-Bromo-1-[(2-methylpropan-2-yl)oxycarbonyl]-1H-pyrazolo[3,4-b]pyridine; tert-Butyl 5-bromo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate; 1-Boc-5-bromopyrazolo[3,4-b]pyridine; 5-Bromo-1H-pyrazolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-5-bromo-1H-pyrazolo[3,4-b]pyridine; 5-Bromo-1-(Boc)-1H-pyrazolo[3,4-b]pyridine; 1299607-55-8; Boc-5-Br-PP
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Bromo-1H-Pyrazolo[3,4-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP (current Good Manufacturing Practice) compliance for use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.