Description

2-(4'-Bromo-[1,1'-Biphenyl]-4-Yl)-2,2-Difluoroethan-1-Ol is a high-value, multi-functional fluorinated biphenyl derivative. This compound serves as a critical advanced pharmaceutical intermediate (API Intermediate) and a versatile building block in modern synthetic chemistry. It is primarily utilized by R&D and production teams in the pharmaceutical, agrochemical, and materials science sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the difluoroethanol and biphenyl motifs contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Acts as a building block for fluorinated organic semiconductors, liquid crystal compounds, and electron-transport materials in display and lighting technologies.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct more complex conjugated systems.
• Fluorine Chemistry Research: Serves as a model compound for studying the influence of gem-difluoro groups on the physical, chemical, and biological properties of organic molecules.
• Ligand & Catalyst Development: Potential precursor for creating novel chiral or bidentate ligands used in asymmetric catalysis.

Basic Information

Product Name	2-(4'-Bromo-[1,1'-Biphenyl]-4-Yl)-2,2-Difluoroethan-1-Ol
CAS No.	1296274-23-1
Molecular Formula	C14H11BrF2O
Molecular Weight	313.14 g/mol
Synonyms	4'-(2,2-Difluoro-2-hydroxyethyl)-4-bromobiphenyl; 2-(4'-Bromobiphenyl-4-yl)-2,2-difluoroethanol; 1-(4'-Bromo[1,1'-biphenyl]-4-yl)-2,2-difluoroethan-1-ol; 4-Bromo-4'-(2,2-difluoro-1-hydroxyethyl)biphenyl; 1296274-23-1; Biphenyl-4,4'-diyl derivative
EINECS	Contact for details

Quality Control

Our 2-(4'-Bromo-[1,1'-Biphenyl]-4-Yl)-2,2-Difluoroethan-1-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient moisture. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.