Description

(R)-1-[3-[4-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Piperidin-1-Yl]-3-Chloropropan-1-One is a high-purity, non-racemic small molecule building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily utilized by medicinal chemists and process development scientists within the pharmaceutical and biotechnology sectors for lead optimization and the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research-scale synthesis of potent and selective kinase inhibitors.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead compound optimization in drug discovery programs.
• Biochemical Probe Development: Serves as a precursor for creating tool compounds to study specific biological pathways and target validation.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and early-stage pharmaceutical development.

Basic Information

Item	Details
Product Name	(R)-1-[3-[4-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Piperidin-1-Yl]-3-Chloropropan-1-One
CAS No.	1288338-96-4
Molecular Formula	C25H25ClN6O2
Molecular Weight	476.96 g/mol
Synonyms	(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-chloropropan-1-one; Acalabrutinib Impurity; ACP-196 Impurity; (R)-Acalabrutinib Intermediate; (R)-Enantiomer of Acalabrutinib precursor; BTK Inhibitor Intermediate; 1H-Pyrazolo[3,4-d]pyrimidine derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of our (R)-1-[3-[4-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Piperidin-1-Yl]-3-Chloropropan-1-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support research and development applications, including chiral purity verification. A Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and related substances is supplied with each shipment to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.