Description

2-(((3-Methyl-4-(2,2,2-Trifluoroethoxy)Pyridin-2-Yl)Methyl)Thio)-1H-Benzo[D]Imidazole Hydrate is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzimidazole-pyridine hybrid structure. This compound is of significant commercial interest for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, especially for proprietary pharmaceutical development.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a critical precursor in multi-step synthetic routes for target molecules in clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its benzimidazole core, a privileged structure in drug discovery.
• Contract Manufacturing: Supplied to CDMOs for scale-up production under current Good Manufacturing Practice (cGMP) conditions for clinical trial material.
• Biochemical Research: Potential use as a tool compound or inhibitor in biochemical assays, exploring enzyme interactions.

Basic Information

Product Name	2-(((3-Methyl-4-(2,2,2-Trifluoroethoxy)Pyridin-2-Yl)Methyl)Thio)-1H-Benzo[D]Imidazole Hydrate
CAS No.	1288338-69-1
Molecular Formula	C₁₆H₁₅F₃N₃O₂S • xH₂O
Molecular Weight	370.37 g/mol (Anhydrous basis)
Synonyms	2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)thio)-1H-benzimidazole Hydrate; 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]thio]-1H-benzimidazole Hydrate; 1H-Benzimidazole, 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)thio)-, hydrate; Benzimidazole derivative CAS 1288338-69-1; TFMP-BIM Hydrate; (3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl benzimidazole-2-thioether hydrate.
EINECS	Contact for details

Quality Control

Our 2-(((3-Methyl-4-(2,2,2-Trifluoroethoxy)Pyridin-2-Yl)Methyl)Thio)-1H-Benzo[D]Imidazole Hydrate is manufactured under strict quality systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for water content, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The hydrate form is stable under these conditions; prolonged exposure to excessive heat, moisture, or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (Anhydrous basis)
Water Content (KF)	As per COA (Hydrate form)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.