Description

4-[1-(tert-Butoxycarbonyl)Piperidin-4-Ylaminosulfonyl]Benzoic Acid is a high-purity, advanced pharmaceutical intermediate featuring a sulfonamide linker and a protected piperidine moiety. This compound is critical for medicinal chemistry research and development, enabling the synthesis of targeted bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly those targeting protein-protein interactions or enzymes where a sulfonamide pharmacophore is desired.
• Protease Inhibitor Development: Used in research for constructing molecules that may act as inhibitors for various protease enzymes, a common target class.
• Kinase Inhibitor Scaffolds: Serves as a versatile component for creating diverse chemical libraries aimed at discovering new kinase inhibitors.
• Chemical Biology Probes: Employed in the development of tool compounds and probes for studying biological pathways and target validation.
• Peptidomimetic Synthesis: The structure is conducive to designing and synthesizing peptidomimetics, which are molecules that mimic peptides but with improved stability and bioavailability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	4-[1-(tert-Butoxycarbonyl)Piperidin-4-Ylaminosulfonyl]Benzoic Acid
CAS No.	1286274-79-0
Molecular Formula	C17H24N2O6S
Molecular Weight	384.45 g/mol
Synonyms	4-[[1-[(1,1-Dimethylethoxy)carbonyl]-4-piperidinyl]amino]sulfonyl]benzoic acid; 4-[(1-Boc-piperidin-4-ylsulfamoyl)]benzoic acid; 4-(N-(1-Boc-piperidin-4-yl)sulfamoyl)benzoic acid; 4-(1-Boc-piperidin-4-ylsulfamoyl)benzoic acid; Benzoic acid, 4-[[[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]amino]sulfonyl]-; BOC-Pip-4-NH-SO2-Bz-OH
EINECS	Contact for details

Quality Control

Our production of 4-[1-(tert-Butoxycarbonyl)Piperidin-4-Ylaminosulfonyl]Benzoic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or development specifications. Our quality systems support delivery under both standard and cGMP-grade requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.