Description

(R)-3-Nitro-2-(Pyrrolidin-3-Yloxy)Pyridine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is of significant value for the research and development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring stereochemical control. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially for central nervous system (CNS) and oncology targets.
• Asymmetric Synthesis: Serves as a precursor for constructing complex molecular architectures with defined stereochemistry in medicinal chemistry programs.
• Chemical Biology Research: Used in the development of molecular probes and tool compounds to study biological pathways and protein-ligand interactions.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of advanced intermediates under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	(R)-3-Nitro-2-(Pyrrolidin-3-Yloxy)Pyridine Hydrochloride
CAS No.	1286208-33-0
Molecular Formula	C9H12ClN3O4
Molecular Weight	261.66 g/mol
Synonyms	(R)-3-Nitro-2-((3-pyrrolidinyl)oxy)pyridine hydrochloride; (R)-2-((Pyrrolidin-3-yl)oxy)-3-nitropyridine hydrochloride; Pyridine, 3-nitro-2-[(3R)-3-pyrrolidinyl]oxy-, hydrochloride (1:1); (R)-2-(Pyrrolidin-3-yloxy)-3-nitropyridine HCl; (R)-3-NO2-2-(3-Pyrrolidinyloxy)Pyridine HCl
EINECS	Contact for details

Quality Control

Our (R)-3-Nitro-2-(Pyrrolidin-3-Yloxy)Pyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and development. A Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.