Description

tert-Butyl (3S,4R)-3-Amino-4-(Trifluoromethyl)Piperidine-1-Carboxylate is a high-value, stereochemically defined piperidine derivative that serves as a critical chiral building block in modern organic synthesis. Its core value lies in the combination of a protected amine and a trifluoromethyl group, enabling the precise construction of complex molecules with enhanced metabolic stability and bioavailability. This advanced intermediate is primarily needed by pharmaceutical R&D and process chemistry teams for the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs.
• API Development: Used in the research and process development of Active Pharmaceutical Ingredients (APIs) requiring a stereochemically pure piperidine scaffold.
• CF3-Bioisostere Incorporation: The trifluoromethyl group acts as a bioisostere, making this compound valuable for optimizing the potency and pharmacokinetic properties of lead compounds.
• Asymmetric Synthesis: Employed in catalytic asymmetric transformations and multi-step syntheses to introduce defined stereocenters.
• Protease Inhibitor Research: Potential building block for the development of protease inhibitors, given the structural features of the piperidine ring.
• Ligand and Catalyst Preparation: Can be utilized to create novel chiral ligands or organocatalysts for asymmetric catalysis.
• Agrochemical Research: Serves as an intermediate in the discovery of advanced agrochemicals with improved activity profiles.

Basic Information

Product Name	tert-Butyl (3S,4R)-3-Amino-4-(Trifluoromethyl)Piperidine-1-Carboxylate
CAS No.	1271811-86-9
Molecular Formula	C11H19F3N2O2
Molecular Weight	268.28 g/mol
Synonyms	1-Boc-3-amino-4-(trifluoromethyl)piperidine (stereoisomer); (3S,4R)-1-(tert-Butoxycarbonyl)-3-amino-4-(trifluoromethyl)piperidine; tert-Butyl (3S,4R)-3-amino-4-(trifluoromethyl)-1-piperidinecarboxylate; (3S,4R)-3-Amino-4-(trifluoromethyl)piperidine-1-carboxylic acid tert-butyl ester; Boc-3-Amino-4-trifluoromethylpiperidine (S,R); 1-N-Boc-3-amino-4-(trifluoromethyl)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl (3S,4R)-3-Amino-4-(Trifluoromethyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral purity (>99% ee), and impurity profiles. We adhere to cGMP principles for advanced pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements for critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.