Description

(3R,5S)-tert-Butyl 3-Amino-5-Fluoropiperidine-1-Carboxylate is a high-purity, chiral piperidine derivative that serves as a critical building block in modern pharmaceutical synthesis. Its value lies in its dual functional groups—a protected amine and a fluorine substituent—which enable precise structural modifications in active pharmaceutical ingredient (API) development. This compound is essential for research and production chemists in the pharmaceutical and agrochemical industries, particularly for creating novel therapeutics and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• API Development: Used in the research and scale-up production of active pharmaceutical ingredients (APIs) requiring fluorinated piperidine scaffolds.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides and herbicides where the fluorine atom enhances biological activity and stability.
• Chemical Biology Research: Employed as a probe or building block in medicinal chemistry for structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in fluorinated compounds.
• Peptidomimetics: Incorporated into the design of peptide mimics to improve metabolic stability and bioavailability.

Basic Information

Product Name	(3R,5S)-tert-Butyl 3-Amino-5-Fluoropiperidine-1-Carboxylate
CAS No.	1271810-13-9
Molecular Formula	C10H19FN2O2
Molecular Weight	218.27 g/mol
Synonyms	1-Boc-3-amino-5-fluoropiperidine (racemic); tert-Butyl 3-amino-5-fluoropiperidine-1-carboxylate; (3R,5S)-1-(tert-Butoxycarbonyl)-5-fluoropiperidin-3-amine; 5-Fluoro-3-aminopiperidine-1-carboxylic acid tert-butyl ester; Boc-3-Amino-5-fluoropiperidine; 1-N-Boc-3-amino-5-fluoropiperidine; 1271810-13-9
EINECS	Contact for details

Quality Control

Our (3R,5S)-tert-Butyl 3-Amino-5-Fluoropiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.