Description

(R)-n-(5'-Chloro-6-((Tetrahydro-2H-Pyran-4-Yl)Methylamino)-2,4'-Bipyridin-2'-Yl)Piperidine-3-Carboxamide is a high-purity, chiral organic compound with a complex molecular architecture designed for advanced pharmaceutical research. This compound serves as a critical building block or intermediate in the development of novel therapeutic agents, particularly those targeting specific biological pathways. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Chemistry Development: Serves as a reference standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Biochemical Tool Compound: May be employed in vitro to probe and validate specific enzyme or receptor targets in biological assays.
• Custom Synthesis: A foundational component for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	(R)-n-(5'-Chloro-6-((Tetrahydro-2H-Pyran-4-Yl)Methylamino)-2,4'-Bipyridin-2'-Yl)Piperidine-3-Carboxamide
CAS No.	1270070-30-8
Molecular Formula	C22H28ClN5O2
Molecular Weight	429.95 g/mol
Synonyms	(R)-5'-Chloro-6-((tetrahydro-2H-pyran-4-yl)methylamino)-N-(piperidin-3-yl)-[2,4'-bipyridine]-2'-carboxamide; (R)-Enantiomer of CAS 1270070-30-8; UNII-9QZ7H4R5FJ (if applicable); (R)-Bipyridine-Piperidine Carboxamide Derivative; (R)-Chloro-THP-Methylamino-Bipyridinyl Piperidinecarboxamide; Potential research code names (e.g., related to BMS-986... series). Contact for specific aliases.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles to support regulatory filings. Our quality commitment aligns with ICH Q7 guidelines for active pharmaceutical ingredients, ensuring traceability and consistency for critical R&D and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.