Description

Phosphonic Acid, p-[2-[[4-[[3-Chloro-4-(2-Pyridinylmethoxy)Phenyl]Amino]-3-Cyano-7-Ethoxy-6-Quinolinyl]Amino]-2-Oxoethyl]-, Diethyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of targeted kinase inhibitors, offering significant value in medicinal chemistry research and development. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of novel therapeutic agents, particularly in oncology.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of small molecule kinase inhibitors for targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the multi-step synthesis of complex active drug substances.
• Biochemical Research: Employed as a tool compound to study specific enzymatic pathways and cellular signaling mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Preclinical Development: Utilized in the production of compounds for pharmacological and toxicological evaluation.

Basic Information

Item	Details
Product Name	Phosphonic Acid, p-[2-[[4-[[3-Chloro-4-(2-Pyridinylmethoxy)Phenyl]Amino]-3-Cyano-7-Ethoxy-6-Quinolinyl]Amino]-2-Oxoethyl]-, Diethyl Ester
CAS No.	1269662-79-4
Molecular Formula	C34H32ClN5O6P
Molecular Weight	664.07 g/mol
Synonyms	Diethyl {4-[2-({4-[(3-chloro-4-{[(pyridin-2-yl)methyl]oxy}phenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}amino)-2-oxoethyl]phenyl}phosphonate; 1269662-79-4; UNII-9W6H8V3A4S; 9W6H8V3A4S; Phosphonic acid, P-[2-[[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]amino]-2-oxoethyl]-, diethyl ester; BDBM50380895; AKOS025310065; CS-0334961; FT-0777687
EINECS	Contact for details

Quality Control

Our Phosphonic Acid, p-[2-[[4-[[3-Chloro-4-(2-Pyridinylmethoxy)Phenyl]Amino]-3-Cyano-7-Ethoxy-6-Quinolinyl]Amino]-2-Oxoethyl]-, Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with research-grade and pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.