Description

Encorafenib (Lgx818) is a potent and selective small-molecule BRAF kinase inhibitor used in targeted cancer therapy. This high-purity active pharmaceutical ingredient (API) is critical for the development and manufacture of innovative oncology treatments. It is primarily required by pharmaceutical companies and research institutions engaged in the formulation of solid dosage forms and clinical research for specific malignancies.

Application

• Primary Active Pharmaceutical Ingredient (API) in the commercial manufacture of targeted cancer therapeutics.
• Key raw material for pharmaceutical R&D focused on BRAF V600E mutation-positive cancers, such as metastatic melanoma and colorectal cancer.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Biochemical research reagent for studying BRAF kinase signaling pathways and mechanisms of drug resistance.
• Pre-clinical and clinical trial material for investigational new drug (IND) applications.
• Formulation development for oral solid dosage forms, including tablets and capsules.

Basic Information

Product Name	Encorafenib (Lgx818)
CAS No.	1269440-17-6
Molecular Formula	C22H27ClFN7O4S
Molecular Weight	540.01 g/mol
Synonyms	LGX818; LGX 818; Encorafenib; Braftovi (Brand Name); (S)-Encorafenib; Methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)anilino]-1H-pyrrolo[2,3-b]pyridin-5-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate; BRAF Inhibitor LGX818
EINECS	Contact for details

Quality Control

Our Encorafenib is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical use. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring compliance with ICH guidelines and current Good Manufacturing Practice (cGMP) standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.10%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.