Description

(5-Chloro-2-Fluoro-4-Methoxyphenyl)Methanol CAS NO 1266177-72-3 is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in its multifunctional structure, which incorporates chloro, fluoro, and methoxy substituents alongside a reactive benzylic alcohol group, enabling precise molecular modifications. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Serves as a versatile precursor in the design and synthesis of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated aromatic core.
• Liquid Crystal & OLED Materials: Used in the synthesis of advanced electronic materials, where its substituted phenyl ring contributes to the desired molecular anisotropy and electronic properties.
• Polymer Science: Acts as a monomer or chain modifier for producing specialty polymers with enhanced chemical resistance, thermal stability, or specific surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and functional group transformations to construct complex, multi-substituted aromatic systems for research.
• Chemical Research & Development: Essential for academic and industrial R&D labs exploring new synthetic methodologies and the structure-activity relationships of fluorinated compounds.

Basic Information

Product Name	(5-Chloro-2-Fluoro-4-Methoxyphenyl)Methanol
CAS No.	1266177-72-3
Molecular Formula	C8H8ClFO2
Molecular Weight	190.60 g/mol
Synonyms	(5-Chloro-2-fluoro-4-methoxyphenyl)methanol; 5-Chloro-2-fluoro-4-methoxybenzyl alcohol; 2-Fluoro-5-chloro-4-methoxybenzyl alcohol; 1-(5-Chloro-2-fluoro-4-methoxyphenyl)methanol; Benzenemethanol, 5-chloro-2-fluoro-4-methoxy-; 1266177-72-3; FC-OMe-BnOH (common abbreviation)
EINECS	Contact for details

Quality Control

Our (5-Chloro-2-Fluoro-4-Methoxyphenyl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.