Description

Debio-1347 is a potent and selective small-molecule inhibitor of the fibroblast growth factor receptor (FGFR) family. This compound is a critical research tool and pharmaceutical intermediate for developing targeted cancer therapies, particularly for tumors driven by FGFR genetic alterations. It is essential for pharmaceutical R&D, academic research, and contract manufacturing organizations (CMOs) focused on oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced investigational new drugs (INDs) targeting FGFR pathways.
• Oncology Research: Used as a reference standard and active compound in preclinical studies to investigate FGFR signaling and tumor biology.
• Biochemical Assay Development: Serves as a potent inhibitor in high-throughput screening (HTS) and enzyme activity assays to discover novel therapeutics.
• Mechanism of Action Studies: Employed in academic and industrial labs to study the specificity and efficacy of FGFR inhibition in various cancer cell lines.
• Drug Discovery & Development: Integral to medicinal chemistry programs aimed at optimizing FGFR inhibitor candidates for improved pharmacokinetics and reduced toxicity.
• Clinical Trial Material (CTM) Synthesis: A critical component in the GMP-compliant manufacturing supply chain for producing clinical-grade drug substances.

Basic Information

Product Name	Debio-1347
CAS No.	1265229-25-1
Molecular Formula	C₂₀H₂₀N₈O₂
Molecular Weight	404.43 g/mol
Synonyms	CH5183284; FGFR Inhibitor (CH5183284); (1E,4E)-1-[5-(4-Cyanophenyl)-1,3,4-oxadiazol-2-yl]-4-[4-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]phenyl]semicarbazide; UNII-7F2I8V73LQ; 7F2I8V73LQ; Debio 1347; CH-5183284
EINECS	Contact for details

Quality Control

Our Debio-1347 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) with detailed chromatograms and full analytical data are provided to ensure compliance with research and development standards. We support custom synthesis with specifications tailored to your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.