Description

6-Bromo-3-(trifluoromethyl)imidazo[1,5-a]pyridine is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. Its unique molecular architecture, featuring both bromo and trifluoromethyl substituents on the imidazopyridine core, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for organic electronic materials, such as ligands for OLEDs or charge-transport materials, due to its rigid, conjugated structure.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies and library synthesis for drug discovery programs, allowing for rapid exploration of chemical space.
• Cross-Coupling Reactions: The bromine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Buchwald-Hartwig) to introduce diverse aryl, alkenyl, or alkynyl groups.
• Fluorine Chemistry: Acts as a valuable scaffold for introducing fluorine atoms into target molecules, a common strategy to improve lipophilicity, metabolic stability, and bioavailability.

Basic Information

Product Name	6-Bromo-3-(trifluoromethyl)imidazo[1,5-a]pyridine
CAS No.	1262619-64-6
Molecular Formula	C8H4BrF3N2
Molecular Weight	265.03 g/mol
Synonyms	6-Bromo-3-(trifluoromethyl)-1H-imidazo[1,5-a]pyridine; 3-(Trifluoromethyl)-6-bromoimidazo[1,5-a]pyridine; Imidazo[1,5-a]pyridine, 6-bromo-3-(trifluoromethyl)-; 6-Bromo-3-trifluoromethylimidazo[1,5-a]pyridine; 1262619-64-6; BTIP; 6-Br-3-CF3-Imidazopyridine
EINECS	Contact for details

Quality Control

Our 6-Bromo-3-(trifluoromethyl)imidazo[1,5-a]pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates for research and development under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.