Description

Vistusertib CAS NO 1262108-14-4 is a potent, selective, and ATP-competitive dual inhibitor of mTORC1 and mTORC2, key regulators of the PI3K/AKT/mTOR signaling pathway. This compound is of significant interest for its role in preclinical and clinical research targeting cancers and other diseases driven by aberrant mTOR signaling. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in oncology drug discovery and development.

Application

• Oncology Research: A critical tool compound for studying the mTOR pathway's role in tumor cell proliferation, survival, and angiogenesis.
• Drug Discovery & Development: Serves as a reference standard and active pharmaceutical ingredient (API) in the development of novel mTOR-targeted cancer therapeutics.
• Biochemical Assays: Used in high-throughput screening and in vitro enzymatic assays to evaluate mTOR kinase inhibition.
• Preclinical Studies: Employed in cell-based studies and animal models to investigate the efficacy and mechanism of action of mTOR inhibition.
• Signal Transduction Research: Facilitates the exploration of cross-talk between the mTOR pathway and other cellular signaling networks.
• Academic Research: Supports fundamental biological research into cellular growth, metabolism, and autophagy.

Basic Information

Product Name	Vistusertib
CAS No.	1262108-14-4
Molecular Formula	C₁₉H₁₈FN₅O₃
Molecular Weight	383.38 g/mol
Synonyms	AZD2014; Vistusertib (AZD2014); 4-[4-[[(3R)-3-Methyl-4-morpholinyl]methyl]-6-[4-(trifluoromethoxy)phenyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-[4-[[(3R)-3-methyl-4-morpholinyl]methyl]-6-[4-(trifluoromethoxy)phenyl]-2-pyrimidinyl]-; AZD 2014; Dual mTORC1/mTORC2 inhibitor AZD2014
EINECS	Contact for details

Quality Control

Our Vistusertib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.