Description

n-[3-[(4As,7As)-2-Amino-5,7-Dihydro-4H-Furo[3,4-D][1,3]Thiazin-7A(4Ah)-Yl]-4-Fluorophenyl]-5-Fluoro-2-Pyridinecarboxamide Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial interest for its role in the research and development of novel therapeutic agents, particularly in targeted oncology. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and API manufacturers engaged in the synthesis of complex small-molecule drugs. Our supply ensures the stringent quality and batch-to-batch consistency critical for preclinical and clinical-stage development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of investigational new drugs, particularly for oncology targets.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the development of novel API candidates.
• Biochemical Research: Used in life science research to study structure-activity relationships (SAR) and biological pathways.
• Preclinical Studies: Supplied in GMP or high-purity grades to support toxicology, pharmacokinetics, and efficacy studies.
• Process Chemistry & Scale-Up: Provides a reliable starting material for process optimization and pilot-scale manufacturing.
• Reference Standard: High-purity material suitable for use as an analytical reference standard in quality control laboratories.

Basic Information

Product Name	n-[3-[(4As,7As)-2-Amino-5,7-Dihydro-4H-Furo[3,4-D][1,3]Thiazin-7A(4Ah)-Yl]-4-Fluorophenyl]-5-Fluoro-2-Pyridinecarboxamide Hydrochloride
CAS No.	1262036-49-6
Molecular Formula	C₁₈H₁₅F₂N₄O₂S·HCl
Molecular Weight	422.86 g/mol (Free base: 386.40 g/mol)
Synonyms	5-Fluoro-N-[4-fluoro-3-[(4aR,7aR)-2-imino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl]phenyl]pyridine-2-carboxamide hydrochloride; UNII-8J8N517V8I; Furo[3,4-d][1,3]thiazine-7a(4H)-carboxamide derivative; (4aR,7aR)-2-Amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazine-7a-carboxamide hydrochloride; CAS 1262036-49-6; A specific kinase inhibitor intermediate. (Contact for specific IUPAC/trade names)
EINECS	Contact for details

Quality Control

Our n-[3-[(4As,7As)-2-Amino-5,7-Dihydro-4H-Furo[3,4-D][1,3]Thiazin-7A(4Ah)-Yl]-4-Fluorophenyl]-5-Fluoro-2-Pyridinecarboxamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral purity analysis, and residual solvent screening, to ensure it meets the exacting standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with ICH Q7 guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment after opening to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0% (Area %)
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	<20 ppm
Assay (Titration)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.