Description

3,6-Difluoro-2-Methoxybenzoyl Chloride is a high-purity, reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to efficiently introduce the difluoromethoxybenzoyl moiety, a key structural motif for modulating the physicochemical and biological properties of target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the difluoro and methoxy groups enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Material Production: Serves as a building block for fluorine-containing aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Employed as a monomer or modifier in the production of specialty polymers, including high-performance engineering plastics and coatings with specific chemical resistance.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Research & Development: Used in academic and industrial R&D labs for exploring new chemical entities and structure-activity relationships (SAR) in drug discovery programs.

Basic Information

Product Name	3,6-Difluoro-2-Methoxybenzoyl Chloride
CAS No.	1261825-37-9
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	2-Methoxy-3,6-difluorobenzoyl chloride; 3,6-Difluoro-2-methoxybenzoic acid chloride; 2-Methoxy-3,6-difluorobenzoic acid chloride; 3,6-Difluoro-o-anisoyl chloride; 2-Methoxy-3,6-difluorobenzoyl chloride; Benzoyl chloride, 3,6-difluoro-2-methoxy-
EINECS	Contact for details

Quality Control

Our 3,6-Difluoro-2-Methoxybenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for sensitive synthesis applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.