Description

4-Chloro-3,5-Difluorobenzoyl Chloride is a high-purity, multi-functional aromatic acid chloride building block essential for advanced organic synthesis. This compound matters because it enables the precise introduction of a highly substituted benzoyl moiety, a critical step in creating complex molecules with tailored properties. It is primarily needed by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for developing active ingredients, as well as in material science for synthesizing specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the chloro-difluoro pattern enhances bioactivity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal monomers, crucial for high-performance displays (LCDs).
• Polymer Chemistry: Employed as a monomer or cross-linking agent in the synthesis of specialty polyamides, polyesters, and engineering plastics with enhanced thermal and chemical resistance.
• Organic Synthesis Reagent: A versatile reagent for Friedel-Crafts acylation and nucleophilic substitution reactions to introduce the 4-chloro-3,5-difluorobenzoyl group.
• Dyestuff and Pigment Intermediate: Used in the manufacture of complex, light-fast dyes and pigments for specialized applications.

Basic Information

Product Name	4-Chloro-3,5-Difluorobenzoyl Chloride
CAS No.	1261799-38-5
Molecular Formula	C7H2Cl2F2O
Molecular Weight	210.99 g/mol
Synonyms	3,5-Difluoro-4-chlorobenzoyl chloride; 4-Chloro-3,5-difluorobenzoic acid chloride; Benzoyl chloride, 4-chloro-3,5-difluoro-; 4-Chloro-3,5-difluorobenzoic acid, acid chloride; 4-Chloro-3,5-difluorobenzoyl chloride (CAS 1261799-38-5); 4-Chloro-3,5-difluorobenzoylchloride; 4-Chloro-3,5-difluorobenzoylchloride (1261799-38-5)
EINECS	Contact for details

Quality Control

Our 4-Chloro-3,5-Difluorobenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.