Description

2-Fluoro-5-Hydroxybenzoyl Chloride is a specialized aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of both a reactive acyl chloride group and a hydroxyl group, which can be selectively protected or further functionalized. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules and active pharmaceutical ingredients (APIs) that require a fluorinated aromatic scaffold.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated aromatic cores in electronic and display materials.
• Polymer Modification: Employed to introduce fluorinated benzoate groups into polymer chains to alter thermal and surface properties.
• Peptide & Protein Research: Useful as a coupling agent or for introducing fluorinated aromatic labels into biomolecules.
• Custom Synthesis & R&D: Serves as a versatile starting material for contract research organizations (CROs) and fine chemical companies exploring new chemical entities.

Basic Information

Product Name	2-Fluoro-5-Hydroxybenzoyl Chloride
CAS No.	1261748-99-5
Molecular Formula	C7H4ClFO2
Molecular Weight	174.56 g/mol
Synonyms	5-Hydroxy-2-fluorobenzoyl chloride; 2-Fluoro-5-hydroxybenzoic acid chloride; 2-Fluorohydroxybenzoyl chloride; (2-Fluoro-5-hydroxyphenyl)carbonyl chloride; 2-Fluoro-5-hydroxy-benzoylchlorid; Benzoyl chloride, 2-fluoro-5-hydroxy-; 1261748-99-5
EINECS	Contact for details

Quality Control

We maintain a strict quality management system aligned with cGMP principles for pharmaceutical intermediates. Every batch of 2-Fluoro-5-Hydroxybenzoyl Chloride is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with each shipment to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and acid chloride nature, it must be kept under an inert atmosphere (e.g., nitrogen or argon) and away from moisture, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.